Laser-assisted nanomedicine for tumor theranostics

The combination of pulsed and CW near-infrared laser light with plasmonic particles such as gold nanorods is gaining relevance for the photoacoustic imaging and photothermal ablation of cancer. Selective targeting of malignant cells with these contrast agents may rely on complementary biochemical and biological strategies, including the use of specific probes or the exploitation of cellular vehicles.

We have developed a platform of PEGylated gold nanorods with plasmonic bands around 800 nm, good biological profiles, stability and efficiency of photoacoustic and photothermal conversion as well as potential to passively accumulate into solid tumors by their enhanced permeability and retention. In order to enhance this potential, we are drawing advantage and inspiration from biological processes to modify these particles for active delivery.

Examples include:

  1. the conjugation with antibodies against cancer antigen 125 (CA125), which is a common biomarker for ovarian lesions;
  2. the termination with inhibitors of carbonic anhydrases 9 and 12 (CAIX and CAXII), which are expressed by hypoxic cells such as those found in the core of solid tumors
  3. by introducing macrophages as a versatile model of cellular vehicles that would phagocytose the particles and home to inflammatory lesions.

For more info please contact Roberto Pini Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo. or Fulvio Ratto Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo.